KRAS Mutation Predicts Pembrolizumab Response in NSCLC

Secret Findings.

The research study was a review of 580 Swedish clients with metastatic NSCLC identified in between 2016 and 2018.
The goal was to figure out the effect of the KRAS mutation and PD-L1 expression on survival after first-line treatment.
Throughout the study duration, pembrolizumab was the only immune checkpoint inhibitor approved for NSCLC.

KRAS anomaly in mix with high PD-L1 expression (≥ 50%) is much better than high PD-L1 alone at predicting reaction to first-line pembrolizumab in patients with metastatic nonsmall cell lung cancer (NSCLC)..

Study Design.

Pembrolizumab is a first-line immunotherapy suggested for metastatic NSCLC.
PD-L1 expression is utilized to forecast who will react to the drug and choose clients for treatment; nevertheless, its not a reputable technique.
The brand-new findings deal with an unmet need to better stratify pembrolizumab responders from nonresponders.

Key Takeaway

Why This Matters.

36% of clients had a KRAS anomaly.
Patients with a KRAS anomaly who received pembrolizumab had substantially much better median total survival compared to patients with wild-type KRAS (23 vs 6 months, respectively; P =.006).
Patients harboring a KRAS mutation varied in terms of overall survival according to PD-L1 expression, with a general survival of 6 months amongst non-expressors, 11 months amongst low expressors, and 17 months amongst high expressors.
No connection was found between PD-L1 expression and total survival with wild-type KRAS.


M. Alexander Otto is a physician assistant with a masters degree in medical science and an acclaimed medical journalist who has worked for a number of major news outlets prior to joining Medscape. He is an MIT Knight Science Journalism fellow. Email:

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A relatively small number of clients were treated with first-line immune checkpoint blockade treatment during the research study, so the findings must be validated in larger research studies.
The effect of co-mutations on immune checkpoint blockade efficacy was not examined.


This is a summary of a preprint research study report led by Ella Eklund of the University of Gothenburg, Sweden, provided to you by Medscape. The research study has actually not been peer-reviewed can be discovered at

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